TY - JOUR AU - Cohrt, A. Emil; Le Quement, Sebastian T.; Nielsen, Thomas E. TI - Solid-Phase Synthesis of NH-1,2,3-Triazoles Using 4,4′-Bismethoxybenzhydryl Azide SN - 0936-5214 SN - 1437-2096 PY - 2014 JO - Synlett JF - Synlett LA - EN VL - 25 IS - 13 SP - 1891 EP - 1895 ET - 2014/06/25 DA - 2014/07/31 KW - click chemistry KW - NH-1,2,3-triazoles KW - solid-phase synthesis KW - cross-coupling KW - azide AB - Readily available 4,4′-bismethoxybenzhydryl azide was found to be a useful building block for the synthesis of NH-1,2,3-triazoles through copper(I)-catalyzed cycloaddition reactions with solid-supported terminal alkynes, followed by acid-mediated deprotection. Peptide-containing NH-1,2,3-triazoles were obtained in good yield and excellent purity (typically >95%). PB - © Georg Thieme Verlag DO - 10.1055/s-0034-1378228 UR - http://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0034-1378228 ER -