TY - JOUR AU - Dendup, Tshewang; Prachyawarakorn, Vilailak; Pansanit, Acharavadee; Mahidol, Chulabhorn; Ruchirawat, Somsak; Kittakoop, Prasat TI - α-Glucosidase Inhibitory Activities of Isoflavanones, Isoflavones, and Pterocarpans from Mucuna pruriens SN - 0032-0943 SN - 1439-0221 PY - 2014 JO - Planta Med JF - Planta Medica LA - EN VL - 80 IS - 07 SP - 604 EP - 608 ET - 2014/04/29 DA - 2014/05/19 KW - Mucuna pruriens KW - Fabaceae KW - α-glucosidase inhibitor KW - isoflavanone KW - isoflavone KW - pterocarpan AB - Three new isoflavanones (1–3) and thirteen known compounds (4–16) were isolated from the roots of Mucuna pruriens. The absolute configurations of isoflavanones 1–3 and parvisoflavanone (4), lespedeol C (5), and uncinanone C (6) were addressed by a circular dichroism technique. Isoflavanones, isoflavones, and pterocarpans of M. pruriens were found to be α-glucosidase inhibitors. Medicarpin (7) and parvisoflavone B (9) were potent α-glucosidase inhibitors (twofold less active than the standard drug acarbose). The production of bioactive metabolites in M. pruriens seems to be season-dependent. PB - Georg Thieme Verlag KG DO - 10.1055/s-0034-1368427 UR - http://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0034-1368427 ER -