TY - JOUR AU - Harlev, Eli; Nevo, Eviatar; Lansky, Ephraim P.; Ofir, Rivka; Bishayee, Anupam TI - Anticancer Potential of Aloes: Antioxidant, Antiproliferative, and Immunostimulatory Attributes SN - 0032-0943 SN - 1439-0221 PY - 2012 JO - Planta Med JF - Planta Medica LA - EN VL - 78 IS - 09 SP - 843 EP - 852 ET - 2012/04/19 DA - 2012/06/14 KW - Aloe vera KW - Xanthorrhoeaceae KW - immunobiology KW - antiproliferative KW - anticancer KW - aloe-emodin KW - acemannan AB - Aloe is a genus of medicinal plants with a notable history of medical use. Basic research over the past couple of decades has begun to reveal the extent of Aloeʼs pharmaceutical potential, particularly against neoplastic disease. This review looks at Aloe, both the genus and the folk medicine, often being called informally “aloes”, and delineates their chemistry and anticancer pharmacognosy. Structures of key compounds are provided, and their pharmacological activities reviewed. Particular attention is given to their free radical scavenging, antiproliferative, and immunostimulatory properties. This review highlights major research directions on aloes, reflecting the enormous potential of natural sources, and of the genus Aloe in particular, in preventing and treating cancer. PB - Georg Thieme Verlag KG DO - 10.1055/s-0031-1298453 UR - http://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0031-1298453 ER -