TY - JOUR AU - Gao, Shuanhu; Wang, Qiaoling; Wang, Gelin; Lomenick, Brett; Liu, Jie; Fan, Chih-Wei; Deng, Lih-Wen; Huang, Jing; Lum, Lawrence; Chen, Chuo TI - The Chemistry and Biology of Nakiterpiosin – C-nor-D-Homosteroids SN - 0936-5214 SN - 1437-2096 PY - 2012 JO - Synlett JF - Synlett LA - EN VL - 23 IS - 16 SP - 2298 EP - 2310 ET - 2012/09/14 DA - 2012/09/21 KW - natural products KW - steroids KW - total synthesis KW - Hedgehog signaling KW - tubulin AB - Isolated from the sponge Terpios hoshinota that causes coral black disease, nakiterpiosin was the first C-nor-D-homosteroid discovered from a marine source. We provide in this account an overview of the chemistry and biology of this natural product. We also include a short history of the synthesis of C-nor-D-homosteroids and the results of some unpublished biological studies of nakiterpiosin.1 Introduction2 Synthesis of C-nor-D-Homosteroids2.1 The Biomimetic Approaches2.2 The Ring-by-Ring Approaches2.3 Miscellaneous Approaches3 Structural Revision of Nakiterpiosin4 Synthesis of Nakiterpiosin5 Biology of Nakiterpiosin6 Conclusion PB - © Georg Thieme Verlag DO - 10.1055/s-0031-1290460 UR - http://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0031-1290460 ER -