TY - JOUR AU - Rotstein, Benjamin H.; Yudin, Andrei K. TI - Aziridine-2-carboxaldehyde Dimers Undergo Homo-Ugi 4-Component-5-center Reactions SN - 0039-7881 SN - 1437-210X PY - 2012 JO - Synthesis JF - Synthesis LA - EN VL - 44 IS - 18 SP - 2851 EP - 2858 ET - 2012/07/11 DA - 2012/09/06 KW - aziridines KW - aldehydes KW - multicomponent reactions KW - heterocycles KW - amphoteric molecules AB - Dimeric α-aziridine aldehydes have been used as the aldehyde component in Ugi and Passerini reactions. The highly reactive mixed anhydride intermediate is subject to nucleophilic attack by the aziridine, leading to ‘homo-Ugi’ β-acylaziridinyl-α-aminoamides. The products can be readily transformed into substituted lactones. PB - © Georg Thieme Verlag DO - 10.1055/s-0030-1260261 UR - http://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0030-1260261 ER -