A citrus polymethoxyflavonoid, nobiletin, is a novel MEK inhibitor that exhibits antitumor metastasis in human fibrosarcoma HT-1080 cells. - Miyata,Y.; Sato,T.; Imada,K.; Dobashi,A.; Yano,M.; Ito,A. (Biochem Biophys Res Commun, 2008)