TY - JOUR AU - Thomas, Noble V.; Meenakshy, C. B.; Leena, Sruthi S.; Deepthi, Ani TI - Stereoselective Synthesis of Dispirooxindoles Incorporating Pyrrolo[2,1-a]isoquinoline via [3+2] Cycloaddition of Azomethine Ylides with a Thiazolo[3,2-a]indole Dipolarophile SN - 0039-7881 SN - 1437-210X PY - 2022 JO - Synthesis JF - Synthesis LA - EN VL - 54 IS - 12 SP - 2885 EP - 2893 DA - 2022/04/05 ET - 2022/02/21 KW - [3+2] cycloaddition KW - azomethine ylide KW - 1,2,3,4-tetrahydroisoquinoline KW - thiazolo[3,2-a]indole KW - spiropyrrolo[2,1-a]isoquinoline AB - Highly regio- and stereoselective synthesis of dispiropyrrolo[2,1-a]isoquinoline-oxindoles have been developed by the one-pot three component reaction of isatins, 1,2,3,4-tetrahydroisoquinoline (THIQ), and a thiazolo[3,2-a]indole derivative. The reaction proceeds regioselectively through an exo-Re face approach of the in situ generated tetrahydroisoquinolium ylides towards the dipolarophile yielding the corresponding [3+2] cycloadducts in excellent yields and stereoselectivity. PB - Georg Thieme Verlag KG DO - 10.1055/a-1777-2423 UR - http://www.thieme-connect.com/products/ejournals/abstract/10.1055/a-1777-2423 ER -