TY - JOUR AU - Höhn, Anne Kathrin; Brambs, Christine E.; Hiller, Grit Gesine Ruth; May, Doris; Schmoeckel, Elisa; Horn, Lars-Christian TI - 2020 WHO Classification of Female Genital Tumors SN - 0016-5751 SN - 1438-8804 PY - 2021 JO - Geburtshilfe Frauenheilkd JF - Geburtshilfe und Frauenheilkunde LA - DE VL - 81 IS - 10 SP - 1145 EP - 1153 DA - 2021/10/06 KW - p16 immunohistochemistry KW - HPV KW - Silva pattern AB - The 2020 WHO classification is focused on the distinction between HPV-associated and HPV-independent squamous cell carcinoma of the lower female genital organs. Differentiating according to HPV association does not replace the process of grading; however, the WHO classification does not recommend any specific grading system. VIN are also differentiated according to whether they are HPV(p16)-associated. HPV-independent adenocarcinoma (AC) of the cervix uteri has an unfavorable prognosis. Immunohistochemical p16 expression is considered to be a surrogate marker for HPV association. HPV-associated AC of the cervix uteri is determined using the prognostically relevant Silva pattern. PB - Georg Thieme Verlag KG DO - 10.1055/a-1545-4279 UR - http://www.thieme-connect.com/products/ejournals/abstract/10.1055/a-1545-4279 ER -