TY - JOUR AU - Anick, David J.; Ives, John A. TI - The silica hypothesis for homeopathy: physical chemistry SN - 1475-4916 SN - 1476-4245 PY - 2007 JO - Homeopathy JF - Homeopathy LA - EN VL - 96 IS - 03 SP - 189 EP - 195 DA - 2017/12/13 KW - homeopathy KW - mechanism KW - silica KW - silicate KW - physical chemistry AB - The ‘silica hypothesis’ is one of several frameworks that have been put forward to explain how homeopathic remedies, which often are diluted beyond the point where any of the original substance remains, might still be clinically effective. We describe here what the silica hypothesis says. From a physical chemistry viewpoint, we explore three challenges that the hypothesis would have to meet in order to explain homeopathy: thermodynamic stability of a large number of distinct structures, pattern initiation at low potencies, and pattern maintenance or gradual evolution at higher potencies. We juxtapose current knowledge about silicates with some of the conventional wisdom about homeopathic remedies, to see how well the latter might be a consequence of the former. We explore variants of the hypothesis including some speculations about mechanisms. We outline laboratory experiments that could help to decide it. PB - Georg Thieme Verlag KG DO - 10.1016/j.homp.2007.03.005 UR - http://www.thieme-connect.com/products/ejournals/abstract/10.1016/j.homp.2007.03.005 ER -