Severe hypertriglyceridemia causing acute pancreatitis in a child with new onset type I diabetes mellitus presenting in ketoacidosis

Abstract

A 10-year-old girl presented with severe diabetic ketoacidosis and a hemoglobin A1c of 17.9%. On hospital day 2, after acidosis had improved, it worsened and she developed excruciating abdominal pain. Her serum triglycerides and lipase levels were found to be extremely high and ultrasound analysis of the pancreas was consistent with acute pancreatitis. She was diagnosed with acute pancreatitis secondary to hypertriglyceridemia. The pancreatitis resolved completely and 2 mo later her hemoglobin A1c was 8.2% and the serum triglycerides were normal. Severe hypertriglyceridemia from insulin deficiency causing pancreatitis in new onset type 1 diabetes mellitus is a rare but serious complication of diabetic ketoacidosis in children.

Keywords

Type 1 diabetes mellitus - diabetic ketoacidosis - pancreatitis - hypertriglyceridemia - autoimmune diabetes