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Thromb Haemost 2017; 117(08): 1637-1643
DOI: 10.1160/TH17-01-0039
Stroke, Systemic or Venous Thromboembolism
Schattauer GmbH

Increased risks of venous thromboembolism in patients with psoriasis

A Nationwide Cohort Study
Wei-Sheng Chung
1   Department of Internal Medicine, Taichung Hospital, Ministry of Health and Welfare, Taichung, Taiwan
2   Department of Health Services Administration, China Medical University, Taichung, Taiwan
3   Department of Healthcare Administration, Central Taiwan University of Science and Technology, Taichung, Taiwan
,
Cheng-Li Lin
4   Management Office for Health Data, China Medical University Hospital, Taichung, Taiwan
5   College of Medicine, China Medical University, Taichung, Taiwan
› Author Affiliations
Further Information

Publication History

Received: 19 January 2017

Accepted after major revision: 03 May 2017

Publication Date:
22 November 2017 (online)

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Summary

Systemic inflammation and hypercoagulability in psoriasis are related to cardiovascular morbidity. The aim of the study was to investigate the incidence and risk of venous thromboembolism (VTE) in patients with psoriasis in Taiwan. We identified inpatients aged ≥ 18 years with a diagnosis of psoriasis and controls at a 1: 1 ratio of frequency matched by sex, age, frequency of medical visits, length of stay, and comorbidities between 2000 and 2010 in the Taiwan National Health Insurance Research Database. Each patient was traced to the date of VTE occurrence, loss to follow-up, death, or the December 31, 2011, whichever occurred first. We analysed 8945 patients with psoriasis and 8945 controls. The patients with psoriasis exhibited a greater incidence rate of VTE (19.2 vs 9.88 per 10 000 person-years) than did the controls. After adjustment for covariates, the patients with psoriasis presented a 2.02-fold risk of VTE (adjusted hazard ratio [aHR] = 2.02, 95% confidence interval [CI] = 1.42–2.88) compared with that in the control cohort. The aHR of VTE was significantly higher in the first year of follow-up (aHR = 3.30, 95% CI = 1.45–7.55) than after one year (aHR = 1.68, 95% CI = 1.13–2.49).

Keywords

Psoriasis - venous thromboembolism (VTE) - cohort study
 

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