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Thromb Haemost 2015; 113(03): 494-504
DOI: 10.1160/TH14-07-0603
Theme Issue Article
Schattauer GmbH

Selenoproteins and cardiovascular stress

Aaron H. Rose
1   Department of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii, USA
,
Peter R. Hoffmann
1   Department of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii, USA
› Author Affiliations
Further Information

Publication History

Received: 14 July 2014

Accepted after minor revision: 18 September 2014

Publication Date:
17 November 2017 (online)

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Summary

Dietary selenium (Se) is an essential micronutrient that exerts its biological effects through its incorporation into selenoproteins. This family of proteins contains several antioxidant enzymes such as the glutathione peroxidases, redox-regulating enzymes such as thioredoxin reductases, a methionine sulfoxide reductase, and others. In this review, we summarise the current understanding of the roles these seleno proteins play in protecting the cardiovascular system from different types of stress including ischaemia-reperfusion, homocysteine dysregulation, myocardial hypertrophy, doxirubicin toxicity, Keshan disease, and others.

Keywords

Cardiovascular - heart - oxidative stress - selenium - selenoproteins
 

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