CD40-CD40L: a Janus-faced interaction

Insight on ► Willecke et al. Thromb Haemost 2014; 112: 379-389.

• References

• 1 Engel D, Seijkens T, Poggi M. et al. The immunobiologiy of CD154-CD40-TRAF interactions in atherosclerosis. Semin Immunol 2009; 21: 308-312.
• 2 Wolf D, Hohmann JD, Wiedemann A. et al. Binding of CD40L to Mac-1’s I-domain involves the EQLKKSKTL motif and mediates leukocyte recruitment and atherosclerosis--but does not affect immunity and thrombosis in mice. Circ Res 2011; 109: 1269-1279.
• 3 Lutgens E, Lievens D, Beckers L. et al. Deficient CD40-TRAF6 signaling in leukocytes prevents atherosclerosis by skewing the immune response toward an antiinflammatory profile. J Exp Med 2010; 207: 391-404.
• 4 Willecke F, Tiwari S, Rupprecht B. et al. Interruption of classic CD40L–CD40 signalling but not of the novel CD40L–Mac-1 interaction limits arterial neointima formation in mice. Thromb Haemost 2014; 112: 379-389.