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Thromb Haemost 2014; 112(04): 678-691
DOI: 10.1160/TH14-02-0146
Theme Issue Article
Schattauer GmbH

Immune functions of platelets

Daniel Duerschmied
1   Department of Cardiology and Angiology I, Heart Center, University of Freiburg, Freiburg, Germany
,
Christoph Bode
1   Department of Cardiology and Angiology I, Heart Center, University of Freiburg, Freiburg, Germany
,
Ingo Ahrens
1   Department of Cardiology and Angiology I, Heart Center, University of Freiburg, Freiburg, Germany
› Author Affiliations
Further Information

Publication History

Received: 17 February 2014

Accepted after major revision: 03 September 2014

Publication Date:
04 December 2017 (online)

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Summary

This review collects evidence about immune and inflammatory functions of platelets from a clinician’s point of view. A focus on clinically relevant immune functions aims at stimulating further research, because the complexity of platelet immunity is incompletely understood and not yet translated into patient care. Platelets promote chronic inflammatory reactions (e.g. in atherosclerosis), modulate acute inflammatory disorders such as sepsis and other infections (participating in the host defense against pathogens), and contribute to exacerbations of autoimmune conditions (like asthma or arthritis). It would hence be obsolete to restrict a description of platelet functions to thrombosis and haemostasis – platelets clearly are the most abundant cells with immune functions in the circulation.

Keywords

Platelet immunology - sepsis - leukocyte function/activation
 

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