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Thromb Haemost 2012; 108(03): 415
DOI: 10.1160/TH12-08-0540
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Adipose tissue-derived PAI-1: A molecular link for thrombo-inflammatory disease states?

Klaus T. Preissner
1   Department of Biochemistry, Medical School, Justus-Liebig-Universität, Giessen, Germany
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Publication History

Received: 02 August 2012

Accepted: 02 August 2012

Publication Date:
25 November 2017 (online)

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Insight on Ekström et al. Thromb Haemost 2012; 108: 485–492.

 

  • References

  • 1 Northcott JM. et al. Adipokines and the cardiovascular system: mechanisms mediating health and disease. Can J Physiol Pharmacol 2012; 90: 1029-1059.
    CrossrefPubMedGoogle Scholar
  • 2 Fain JN. Release of inflammatory mediators by human adipose tissue is enhanced in obesity and primarily by the nonfat cells: a review. Mediators Inflamm 2010; 2010: 513948.
    PubMedGoogle Scholar
  • 3 Samad F, Loskutoff DJ. The fat mouse: a powerful genetic model to study elevated plasminogen activator inhibitor 1 in obesity/NIDDM. Thromb Haemost 1997; 78: 652-655.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 4 Zaidi M. et al. Minireview: The link between fat and bone: does mass beget mass?. Endocrinology 2012; 153: 2070-2075.
    CrossrefPubMedGoogle Scholar
  • 5 Ekström M. et al. Stimulated in vivo synthesis of plasminogen activator inhibitor-1 in human adipose tissue. Thromb Haemost 2012; 108: 485-492.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 6 Nieswandt B. et al. Ischaemic stroke: a thrombo-inflammatory disease?. J Physiol 2011; 589: 4115-4123.
    CrossrefPubMedGoogle Scholar
  • 7 Van De Craen B. et al. The biochemistry, physiology and pathological roles of PAI-1 and the requirements for PAI-1 inhibition in vivo. Thromb Res. 2012 epub ahead of print.
    PubMedGoogle Scholar