Download PDF
Thromb Haemost 2012; 108(02): 399-401
DOI: 10.1160/TH12-03-0145
Letters to the Editor
Schattauer GmbH

Prevalence of factor V Leiden and G20210A prothrombin mutation in the Dutch Famine Birth Cohort: A possible survival advantage?

Federico Lussana
1   Divisione di Medicina Generale III, Azienda Ospedaliera San Paolo. Dipartimento di Medicina, Chirurgiae Odontoiatria, Università degli Studi di Milano, Milan, Italy
,
Susanne R. de Rooij
2   Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Center, University of Amsterdam, The Netherlands
,
Marjolein Veenendaal
2   Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Center, University of Amsterdam, The Netherlands
,
Cristina Razzari
1   Divisione di Medicina Generale III, Azienda Ospedaliera San Paolo. Dipartimento di Medicina, Chirurgiae Odontoiatria, Università degli Studi di Milano, Milan, Italy
,
Gessica Fontana
1   Divisione di Medicina Generale III, Azienda Ospedaliera San Paolo. Dipartimento di Medicina, Chirurgiae Odontoiatria, Università degli Studi di Milano, Milan, Italy
,
Elena M. Faioni
1   Divisione di Medicina Generale III, Azienda Ospedaliera San Paolo. Dipartimento di Medicina, Chirurgiae Odontoiatria, Università degli Studi di Milano, Milan, Italy
,
Rebecca C. Painter
3   Department of Gynaecology and Obstetrics, Amsterdam Medical Center, University of Amsterdam, The Netherlands
,
Saskia Middeldorp
4   Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
,
Marco Cattaneo
1   Divisione di Medicina Generale III, Azienda Ospedaliera San Paolo. Dipartimento di Medicina, Chirurgiae Odontoiatria, Università degli Studi di Milano, Milan, Italy
,
Tessa J. Roseboom
2   Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Center, University of Amsterdam, The Netherlands
3   Department of Gynaecology and Obstetrics, Amsterdam Medical Center, University of Amsterdam, The Netherlands
› Author Affiliations
Further Information

Publication History

Received: 05 March 2012

Accepted after major revision: 29 April 2012

Publication Date:
25 November 2017 (online)

    Permissions and Reprints

 

 

  • References

  • 1 Rees DC, Cox M, Clegg JB. World distribution of factor V Leiden. Lancet 1995; 346: 1133-1134.
    CrossrefPubMedGoogle Scholar
  • 2 Rosendaal FR, Doggen CJ, Zivelin A. et al. Geographic distribution of the 20210 G to A prothrombin variant. Thromb Haemost 1998; 79: 706-708.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 3 Martinelli I. Risk factors in venous thromboembolism. Thromb Haemost 2001; 86: 395-403.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 4 Seligsohn U, Lubetsky A. Genetic susceptibility to venous thrombosis. N Engl J Med 2001; 344: 1222-1231.
    CrossrefPubMedGoogle Scholar
  • 5 Poort SR, Rosendaal FR, Reitsma PH. et al. A common genetic variation in the 3'-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis. Blood 1996; 88: 3698-3703.
    PubMedGoogle Scholar
  • 6 Bertina RM, Koeleman B P, Koster T. et al. Mutation in blood coagulation factor V associated with resistance to activated protein C. Nature 1994; 369: 64-67.
    CrossrefPubMedGoogle Scholar
  • 7 Robertson L, Wu O, Langhorne P. et al. Thrombophilia in pregnancy: a systematic review. Br J Haematol 2006; 132: 171-196.
    CrossrefPubMedGoogle Scholar
  • 8 Lindqvist PG, Svensson PJ, Dahlback B. et al. Factor V Q506 mutation (activated protein C resistance) associated with reduced intrapartum blood loss--a possible evolutionary selection mechanism. Thromb Haemost 1998; 79: 69-73.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 9 Kerlin BA, Yan SB, Isermann BH. et al. Survival advantage associated with heterozygous factor V Leiden mutation in patients with severe sepsis and in mouse endotoxemia. Blood 2003; 102: 3085-3092.
    CrossrefPubMedGoogle Scholar
  • 10 van Dunne FM, de Craen AJ, Heijmans BT. et al. Gender-specific association of the factor V Leiden mutation with fertility and fecundity in a historic cohort. The Leiden 85-Plus Study. Hum Reprod 2006; 21: 967-971.
    CrossrefPubMedGoogle Scholar
  • 11 Cohn DM, Repping S, Buller HR. et al. Increased sperm count may account for high population frequency of Factor V Leiden. J Thromb Haemost 2010; 08: 513-516.
    CrossrefPubMedGoogle Scholar
  • 12 Gopel W, Ludwig M, Junge AK. et al. Selection pressure for the factor-V-Leiden mutation and embryo implantation. Lancet 2001; 358: 1238-1239.
    CrossrefPubMedGoogle Scholar
  • 13 van Mens TE, Kaandorp S P, Goddijn M. et al. Women with factor V Leiden mutation and unexplained recurrent miscarriage have a shorter time to pregnancy than non-carriers; an evolutionary advantage?. Abstracts of the XXIII Congress of the International Society on Thrombosis and Haemostasis OTH 093 J Thromb Haemost. 2011 suppl 2 753.
    PubMedGoogle Scholar
  • 14 Stein Z, Susser M, Saenger G. et al. Famine and Human Development. The Dutch Hunger Winter of 1944-45. New York: Oxford University Press; 1975
    Google Scholar
  • 15 Roseboom TJ, van der Meulen JH, Osmond C. et al. Plasma lipid profiles in adults after prenatal exposure to the Dutch famine. Am J Clin Nutr 2000; 72: 1101-1106.
    CrossrefPubMedGoogle Scholar
  • 16 Poort SR, Bertina RM, Vos HL. Rapid detection of the prothrombin 20210 A variation by allele specific PCR. Thromb Haemost 1997; 78: 1157-1158.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 17 de Ronde H, Bertina RM. Laboratory diagnosis of APC-resistance: a critical evaluation of the test and the development of diagnostic criteria. Thromb Haemost 1994; 72: 880-886.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 18 Roseboom TJ, van der Meulen JH, Osmond C. et al. Adult survival after prenatal exposure to the Dutch famine 1944-45. Paediatr Perinat Epidemiol 2001; 15: 220-225.
    CrossrefPubMedGoogle Scholar
  • 19 Benfield TL, Dahl M, Nordestgaard BG. et al. Influence of the factor V Leiden mutation on infectious disease susceptibility and outcome: a population-based study. J Infect Dis 2005; 192: 1851-1857.
    CrossrefPubMedGoogle Scholar