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Thromb Haemost 2008; 99(02): 290-294
DOI: 10.1160/TH07-10-0589
Theme Issue Article
Schattauer GmbH

Role of proteolysis in development of murine adipose tissue

Valerie Christiaens
1   Center for Molecular and Vascular Biology, KU Leuven, Leuven, Belgium
,
Ilse Scroyen
1   Center for Molecular and Vascular Biology, KU Leuven, Leuven, Belgium
,
H. Roger Lijnen
1   Center for Molecular and Vascular Biology, KU Leuven, Leuven, Belgium
› Author Affiliations
Further Information

Publication History

Received: 02 October 2007

Accepted after major revision: 19 January 2007

Publication Date:
24 November 2017 (online)

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Summary

Obesity is a common disorder, and related diseases such as diabetes, atherosclerosis, hypertension, cardiovascular disease and cancer are a major cause of mortality and morbidity inWesterntype societies. Development of obesity is associated with extensive modifications in adipose tissue involving adipogenesis, angiogenesis and extracellular matrix proteolysis. The fibrinolytic (plasminogen/plasmin) and matrix metalloproteinase (MMP) systems cooperate in these processes. A nutritionally induced obesity model in transgenic mice has been used extensively to study the role of the fibrinolytic and MMP systems in the development of obesity. These studies support a role of both systems in adipogenesis and obesity, and suggest that modulation of proteolytic activity may affect development of adipose tissue.

Keywords

Animal models - fibrinolysis inhibitors - gene knock-out - matrix metalloproteinases - obesity
 

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