Thromb Haemost 2008; 99(02): 451-452
DOI: 10.1160/TH07-06-0404
Letters to the Editor
Schattauer GmbH

Comparison of the effect of different homocysteine concentrations on clot formation using human plasma and purified fibrinogen

Rita Marchi
1   Centro de Medicina Experimental, Laboratorio de Fisiopatología, Sección Biología del Desarrollo de la Hemostasia; Instituto Venezolano de Investigaciones Científicas, IVIC, Caracas, República Bolivariana de Venezuela
,
Zoila Carvajal
1   Centro de Medicina Experimental, Laboratorio de Fisiopatología, Sección Biología del Desarrollo de la Hemostasia; Instituto Venezolano de Investigaciones Científicas, IVIC, Caracas, República Bolivariana de Venezuela
,
John W. Weisel
2   Department of Cell and Developmental Biology, University of Pennsylvania, School of Medicine, Philadelphia, Pennsylvania, USA
› Author Affiliations
Further Information

Publication History

Received: 12 June 2007

Accepted after major revision: 28 January 2007

Publication Date:
24 November 2017 (online)

 

 
  • References

  • 1 Lauricella AM, Quintana IL, Kordich LC. Effects of homocysteine thiol group on fibrin networks: another possible mechanism of harm. Thromb Res 2002; 107: 75-79.
  • 2 Majors AK, Sengupta S, Willard B. et al. Homocysteine binds to human plasma fibronectin and inhibits its interaction with fibrin. Arterioscler Thromb Vasc Biol 2002; 22: 1354-1359.
  • 3 Undas A, Brozek J, Jankowski M. et al. Plasma homocysteine affects fibrin clot permeability and resistance to lysis in human subjects. Arterioscler Thromb Vasc Biol 2006; 26: 1397-1404.
  • 4 Hajjar KA, Jacovina AT. Modulation of Annexin II by homocysteine: implications for atherothrombosis. J Invest Med 1998; 46: 364-368.
  • 5 Dardik R, Varon D, Tamarin I. et al. Homocysteine and oxidized low density lipoprotein enhance platelet adhesion to endothelial cells under flow conditions: distinct mechanisms of thrombogenic modulation. Thromb Haemost 2000; 83: 338-344.
  • 6 Nardulli M, Durlach V, Pepe G. et al. Mechanism for the homocysteine-enhanced antifibrinolytic potential of lipoprotein(a) in human plasma. Thromb Haemost 2005; 94: 75-81.
  • 7 Marchi R, Meyer MH, de Bosch NB. et al. A novel mutation (deletion of Aα-Asn 80) in an abnormal fibrinogen: Fibrinogen Caracas VI. Consequences of disruption of the coiled-coil for the polymerization of fibrin: peculiar clot structure and diminished stiffness of the clot. Blood Coagul Fibrinolysis 2004; 15: 559-567.