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Thromb Haemost 2005; 94(06): 1306-1311
DOI: 10.1160/TH05-03-0158
Cell Signalling and Vessel Remodelling
Schattauer GmbH

Endurance training reduces circulating asymmetric dimethylarginine and myeloperoxidase levels in persons at risk of coronary events

Bernhard Richter   *
1   Department of Internal Medicine II, Division of Cardiology, Medical University of Vienna, Austria
,
Alexander Niessner   *
1   Department of Internal Medicine II, Division of Cardiology, Medical University of Vienna, Austria
,
Martina Penka
2   Department of Cardiology and Emergency Medicine, Wilhelminen-Hospital, Vienna, Austria
,
Marija Grdić
3   Department of Medical Biochemistry and Hematology, Faculty of Pharmacy and Biochemistry, Zagreb, Croatia
,
Sabine Steiner
4   Department of Internal Medicine II, Division of Angiology, Medical University of Vienna, Austria
,
Barbara Strasser
5   Department of Internal Medicine IV, Division of Sports Medicine, Medical University of Vienna, Austria
,
Sophie Ziegler
4   Department of Internal Medicine II, Division of Angiology, Medical University of Vienna, Austria
,
Gerlinde Zorn
1   Department of Internal Medicine II, Division of Cardiology, Medical University of Vienna, Austria
,
Gerald Maurer
1   Department of Internal Medicine II, Division of Cardiology, Medical University of Vienna, Austria
,
Vera Simeon-Rudolf
6   Institute for Medical Research and Occupational Health, Zagreb, Croatia
,
Johann Wojta
1   Department of Internal Medicine II, Division of Cardiology, Medical University of Vienna, Austria
,
Kurt Huber
1   Department of Internal Medicine II, Division of Cardiology, Medical University of Vienna, Austria
2   Department of Cardiology and Emergency Medicine, Wilhelminen-Hospital, Vienna, Austria
› Author Affiliations
Further Information

Publication History

Received 06 March 2005

Accepted after resubmission 22 August 2005

Publication Date:
07 December 2017 (online)

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Summary

Asymmetric dimethylarginine (ADMA), myeloperoxidase (MPO) and paraoxonase 1 (PON1) are directly involved in the pathogenesis of atherosclerosis by modulation of oxidative stress and/or NO bioavailability. We aimed to assess whether endurance exercise which is known to be cardioprotective could beneficially affect these novel risk markers. Thirty-two subjects (31–68 yrs, 56% males) with elevated cardiovascular risk including ten patients with coronary artery disease volunteered for a supervised 12-week endurance training (196 ± 15 min/week).Their fitness evaluated by 2 km test runs improved significantly after training (pre: 17.3±0.8 vs. post: 15.7±0.9min, p<0.001). ADMA (pre: 0.94±0.03 vs. post: 0.75±0.04 μmol l−1) and MPO (pre:296.8±22.2 vs.post:185.7±19.5 ng ml−1) serum levels decreased significantly by 17.6±4.6% and 28.5±7.5%, respectively, after training (both p<0.001).Their down-regulation was inversely correlated (ADMA: r=-0.609, p<0.001, MPO: r=-0.437, p=0.014) with the up-regulation of plasma cGMP levels (Cyclic-guanosine 3`,5`-monophosphate; pre: 1.6±0.12 vs. post: 2.21±0.2 μmol ml−1, p=0.001) reflecting NO production. PON1 activity towards phenylacetate was not significantly influenced by training (pre: 133±6 vs. post: 130±5 μmol ml−1 min−1, p=0.375). In a matched inactive control group (n=16) ADMA, MPO, cGMP levels and PON1 activity did not change over time. ADMA, MPO and cGMP changes were significantly different between participants and controls (all p<0.05). Regular endurance exercise was successful in reducing the circulating levels of two promising cardiovascular risk markers, ADMA and MPO, in persons prone to cardiac events. These changes may result in numerous antiatherosclerotic effects such as improvement of NO bioavailability, reduction of oxidative stress and lipid peroxidation.

Keywords

Exercise - atherosclerosis - asymmetric dimethylarginine - myeloperoxidase - paraoxonase 1

* Both authors equally contributed to this study None of the authors has a conflict of interest


 

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