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Thromb Haemost 2005; 93(05): 876-879
DOI: 10.1160/TH04-08-0508
Blood Coagulation, Fibrinolysis and Cellular Haemostasis
Schattauer GmbH

Prevalence of venous thromboembolism at a teaching hospital in Okinawa, Japan

Mitsumasa Kishimoto
1   Division of Rheumatology, New York University, New York, USA, and Department of Public Health, Juntendo University, Tokyo, Japan
2   Department of Medicine, University of Hawaii, John A. Burns School of Medicine, Honolulu, Hawaii, USA
,
Hwee Yong Lim
2   Department of Medicine, University of Hawaii, John A. Burns School of Medicine, Honolulu, Hawaii, USA
,
Yasuharu Tokuda
3   Department of Medicine, Okinawa Chubu Hospital, Okinawa, Japan
,
Masashi Narita
3   Department of Medicine, Okinawa Chubu Hospital, Okinawa, Japan
,
Hidetaka Kitazono
3   Department of Medicine, Okinawa Chubu Hospital, Okinawa, Japan
,
Hiroki Ito
2   Department of Medicine, University of Hawaii, John A. Burns School of Medicine, Honolulu, Hawaii, USA
,
Todd B. Seto
2   Department of Medicine, University of Hawaii, John A. Burns School of Medicine, Honolulu, Hawaii, USA
,
Kenneth N. Sumida
2   Department of Medicine, University of Hawaii, John A. Burns School of Medicine, Honolulu, Hawaii, USA
,
Rebecca P. Gelber
2   Department of Medicine, University of Hawaii, John A. Burns School of Medicine, Honolulu, Hawaii, USA
› Author Affiliations
Further Information

Publication History

Received 17 August 2004

Accepted after resubmission 02 February 2005

Publication Date:
11 December 2017 (online)

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Summary

Limited data suggest that Asian Americans may have a lower risk of venous thromboembolism (VTE) than Caucasians. However, the actual prevalence of VTE among Asians remains controversial, and has not been described in Japan. We studied all 131,060 patients hospitalized at a single medical centre in Japan (January 1987 – December 1999). Patients with VTE were identified through discharge diagnoses. Hospital records were reviewed for information on patient demographics, risk factors, and diagnostic modalities. VTE occurred in 0.11% of admissions (n=141, 95%CI 0.09–0.13%). Mean age (±SD) was 64±17 years, 70% were women, 91% had deep vein thrombosis, and 29% pulmonary embolism. Among hospitalized patients 50–69 years old, VTE was significantly more common among women than men (0.31% vs. 0.08%; OR 3.88; 95%CI 1.45–6.31). We found a low prevalence of VTE in Japan compared to that reported in the US. Future studies are needed to clarify the reasons for our findings.

Keywords

Thromboembolism - Japan - prevalence
 

  • References

  • 1 White RH, Zhou H, Romano PS. Incidence of idiopathic deep venous thrombosis and secondary thromboembolism among ethnic groups in California. Ann Intern Med 1998; 128: 737-40.
    CrossrefPubMedGoogle Scholar
  • 2 Stein PD, Patel KC, Kalra NK. et al. Deep venous thrombosis in a general hospital. Chest 2002; 122: 960-2.
    CrossrefPubMedGoogle Scholar
  • 3 Anderson FA, Wheeler HB, Goldberg RJ. et al. A population-based perspective of the hospital incidence and case-fatality rates of deep vein thrombosis and pulmonaryembolism. Arch Intern Med 1991; 151: 933-8.
    CrossrefPubMedGoogle Scholar
  • 4 Goldhaber SZ, Tapson VF. Aprospective registry of 5,451 patients with ultrasound-confirmed deep vein thrombosis. Am J Cardiol 2004; 93: 259-62.
    CrossrefPubMedGoogle Scholar
  • 5 Tinckler LF. Absence of pulmonary embolism in Asians?. Br Med J 1964; 1: 502.
    PubMedGoogle Scholar
  • 6 Liu HSY, Kho BCS, Chan JCW. et al. Venous thromboembolism in the Chinese population-experience in a regional hospital in Hong Kong. Hong Kong Med J 2002; 8: 400-5.
    Google Scholar
  • 7 Klatsky AL, Armstrong MA, Poggi J. Risk of pulmonary embolism and/or deep venous thrombosis in Asian-Americans. Am J Cardiol 2000; 85: 1334-7.
    CrossrefPubMedGoogle Scholar
  • 8 Liam CK, Ng SC. review of patients with deep vein thrombosis diagnosed at University hospital, Kuala Lumpur. Ann Acad Med Singapore 1990; 19: 837-40.
    PubMedGoogle Scholar
  • 9 Kueh YK, Wang TL, Teo CP. et al. Acute deep vein thrombosis in hospital practice. Ann Acad Med Singapore 1992; 21: 345-8.
    PubMedGoogle Scholar
  • 10 Lee LH, Gu KQ, Heng D. Deep vein thrombosis is not rare in Asia – The Singapore General Hospital experience. Ann Acad Med Singapore 2002; 31: 761-4.
    PubMedGoogle Scholar
  • 11 Liew NC, Moissinac K, Gul Y. Postoperative venous thromboembolism in Asia: a critical appraisal of its incidence. Asian J Surg 2003; 26: 154-8.
    CrossrefPubMedGoogle Scholar
  • 12 Stein PD, Kayali F, Olson RE. et al. Pulmonary thromboembolism in Asians/Pacific Islanders in the United States: analysis of data from the national hospital discharge surveyand the United States Bureauof the Census. Am J Med 2004; 116: 435-42.
    CrossrefPubMedGoogle Scholar
  • 13 Heit JA, Silverstein MD, Mohr DN. et al. Risk factors for deep vein thrombosis and pulmonary embolism: a population-based case-control study. Arch Intern Med 2000; 160: 809-15.
    CrossrefPubMedGoogle Scholar
  • 14 Geerts WH, Heit JA, Clagett GP. et al. Prevention of venous thromboembolism. Chest 2001; 119: 132S-175S.
    CrossrefPubMedGoogle Scholar
  • 15 Rees DC, Cox M, Clegg JB. World distribution of factor V Leiden. Lancet 1995; 346: 1133-4.
    CrossrefPubMedGoogle Scholar
  • 16 Lee DH, Henderson PA, Blajchman MA. Prevalence of factor V Leiden in a Canadian blood donor population. CMAJ 1996; 155: 285-9.
    PubMedGoogle Scholar
  • 17 Ridker PM, Miletich JP, Hennekens CH. et al. Ethnic distribution of factor V Leiden in 4047 men and women: implications for venous thromboembolism screening. JAMA 1997; 277: 1305-7.
    CrossrefPubMedGoogle Scholar
  • 18 Rosendaal FR. Risk factors for venous thrombosis: prevalence, risk, and interaction. Semin Hematol 1997; 34: 171-87.
    PubMedGoogle Scholar
  • 19 Miyata T, Kawasaki T, Fujimura H. et al. The prothrombin gene G20210Amutation is not found among Japanese patients with deep vein thrombosis and healthy individuals [letter]. Blood Coagul Fibrinolysis 1998; 9: 451-2.
    CrossrefPubMedGoogle Scholar
  • 20 Alfthan G, Aro A, Gey KF. Plasma homocysteine and cardiovascular disease mortality. Lancet 1997; 349: 97.
    PubMedGoogle Scholar
  • 21 Willcox BJ, Suzuki M, Willcox DC. et al. Homocysteine levels in Okinawan-Japanese. J Investigative Med 2000; 48: 205A.
    PubMedGoogle Scholar
  • 22 Silverstein MD, Heit JA, Mohr DN. et al. Trends in the incidence of deep vein thrombosis and pulmonary embolism: a 25-year population-based study. Arch Intern Med 1998; 158: 585-93.
    CrossrefPubMedGoogle Scholar
  • 23 Cushman M, Tsai A, Heckbert SR. et al. Incidence rates, case fatality, and recurrence rates of deep vein thrombosis and pulmonary embolus: the Longitudinal Investigation of Thromboembolism Etiology (LITE). Thromb Haemost 2001; 86 (Suppl. 01) (suppl) OC2349 Abstract.
    PubMedGoogle Scholar
  • 24 Kniffin Jr. WD, Baron JA, Barrett J. et. al The epidemiology of diagnosed pulmonary embolism and deep venous thrombosis in elderly. Arch Intern Med 1994; 154: 861-6.
    CrossrefPubMedGoogle Scholar
  • 25 Nordstrom M, Lindblad B, Bergqvist D. et al. A prospective study of the incidence of deep-vein thrombosis within a defined urban population. J Intern Med 1992; 232: 155-60.
    CrossrefPubMedGoogle Scholar
  • 26 Oger E. Incidence of venous thromboembolism: A community-based study in Western France. Thromb Haemost 2000; 83: 657-60.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 27 White RH. The epidemiology of venous thromboembolism. Circulation 2003; 107: I-4-I-8.
    PubMedGoogle Scholar