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Thromb Haemost 2005; 93(03): 468-474
DOI: 10.1160/TH04-04-0251
Blood Coagulation, Fibrinolysis and Cellular Haemostasis
Schattauer GmbH

The ABO blood group genotype and factor VIII levels as independent risk factors for venous thromboembolism

Isabel Tirado
1   Hospital de la Santa Creu i Sant Pau, Departament d’Hematologia, Unitat d’Hemostàsia i Trombosis, Barcelona, Spain
,
José Mateo
1   Hospital de la Santa Creu i Sant Pau, Departament d’Hematologia, Unitat d’Hemostàsia i Trombosis, Barcelona, Spain
,
José Manuel Soria
1   Hospital de la Santa Creu i Sant Pau, Departament d’Hematologia, Unitat d’Hemostàsia i Trombosis, Barcelona, Spain
,
Arturo Oliver
2   Fundació Puigvert, Haematology Department, Barcelona, Spain
,
Elisabeth Martínez-Sánchez
1   Hospital de la Santa Creu i Sant Pau, Departament d’Hematologia, Unitat d’Hemostàsia i Trombosis, Barcelona, Spain
,
Cristina Vallvé
1   Hospital de la Santa Creu i Sant Pau, Departament d’Hematologia, Unitat d’Hemostàsia i Trombosis, Barcelona, Spain
,
Monserrat Borrell
1   Hospital de la Santa Creu i Sant Pau, Departament d’Hematologia, Unitat d’Hemostàsia i Trombosis, Barcelona, Spain
,
Teresa Urrutia
1   Hospital de la Santa Creu i Sant Pau, Departament d’Hematologia, Unitat d’Hemostàsia i Trombosis, Barcelona, Spain
,
Jordi Fontcuberta
1   Hospital de la Santa Creu i Sant Pau, Departament d’Hematologia, Unitat d’Hemostàsia i Trombosis, Barcelona, Spain
› Author AffiliationsGrant support: This study was supported partially by grants HL70751 from the NIH (USA), SAF2002–03449 and by FEDER funds (Spanish Ministry of Science and Technology), from FIS 020506 from the Fondo Investigación Sanitaria (Spanish Ministry of Health), from Fundació La Caixa and Fundació d’Investigació Sant Pau. J. M. Soria is supported by the FIS 99/3048 from the Fondo Investigación Sanitaria (Spanish Ministry of Health).
Further Information

Publication History

Received 22 April 2004

Accepted after resubmission 10 January 2004

Publication Date:
14 December 2017 (online)

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Summary

Factor VIII (FVIII), von Willebrand factor (vWF) and the ABO blood groups have been associated with thrombosis. The ABO locus has functional effects on vWF and FVIII levels and is genetically correlated with FVIII, vWF and thrombosis. We carried out a case-control study to assess the role of FVIII, vWF and ABO types on thrombotic risk. We analyzed 250 patients with venous thrombosis and 250 unrelated controls. FVIII, vWF and other factors related to thrombophilia were measured, ABO groups were analyzed by genotyping. FVIII and vWF were higher in non-O individuals. Group O was more frequent in the controls (44.3% v 23.3%; difference 21.1%; 95% CI: 13.0–29.3%) and Group A in patients (59.2% v. 41.5%; difference 17.7%, 95% CI: 9.1–26.4%). Individuals carrying the A1 allele had a higher risk of thrombosis (OR 2.6; 95% CI, 1.8–3.8). The risk attributed to vWF disappeared after adjusting for the ABO group. Patients with FVIII above the 90th percentile had a high thrombotic risk (adjusted OR 3.7; 95%CI, 2.1–6.5), and a high risk of recurrence (OR 2.3; 95%CI: 1.3–4.1). In conclusion, high FVIII levels and non-O blood groups, likely those with the A1 allele, are independent risk factors for venous thromboembolism and should be considered in evaluating of thrombophilia.

Keywords

Factor VIII - ABO genotypes - von Willebrand factor - venous thrombosis - thrombophilia
 

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