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Thromb Haemost 2004; 92(05): 1060-1065
DOI: 10.1160/TH04-04-0228
Wound Healing and Inflammation/Infection
Schattauer GmbH

Association between the Thr715Pro P-selectin gene polymorphism and soluble P-selectin levels in a multiethnic population in South London

Michelle A. Miller
1   Department of Community Health Sciences, St George’s Hospital Medical School, London UK
,
Sally M. Kerry
1   Department of Community Health Sciences, St George’s Hospital Medical School, London UK
,
Yanbin Dong
2   Georgia Prevention Institute, Medical College of Georgia, Augusta, Georgia, USA
,
Pasquale Strazzullo
3   Department of Clinical & Experimental Medicine, Federico II University, Naples, Italy
,
Francesco P. Cappuccio
1   Department of Community Health Sciences, St George’s Hospital Medical School, London UK
› Author AffiliationsFinancial support: The WHSS has received support from the former Wandsworth and South Thames Regional Health Authorities, NHS R & D Directorate, British Heart Foundation, former British Diabetic Association and The Stroke Association. Dr. Miller was supported by the British Heart Foundation (Project Grant PG/2001023), the IMMIDIET Project (EC QLK1-CT-2000-00100) and The Wellcome Trust VIP Award.
Further Information

Publication History

Received 14 April 2004

Accepted after resubmission 27 July 2004

Publication Date:
04 December 2017 (online)

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Summary

The aim was to investigate whether the Thr715Pro P-selectin polymorphism is associated with soluble P-selectin (sP-selectin) levels in individuals from different ethnic groups. Plasma sPselectin and Thr715Pro (A/C) P-selectin gene polymorphism were measured in 237 white (106 females), 177 black African origin (92 females) and 201 South Asian (94 females) individuals living in England. All were free from coronary heart disease (CHD), stroke and other cardiovascular disease, diabetes, drug therapy for hypertension or high lipids, hormone replacement therapy or oral contraceptive pill. The Thr715Pro C allele was rare in blacks (0.8%) and intermediate in South Asians (3.0%) compared to whites (11.2%; p <0.001). sP-selectin levels were significantly lower in the individuals with the AC or CC compared to the AA genotype in both whites (-25% (95% C.I. -33.3 to -16.9); p <0.001) and South Asians (-25.2% (-40.5 to -6.1); p <0.012). There was insufficient power for this analysis in blacks. In conclusion, in whites and South Asians the C allele of the Thr715Pro P-selectin polymorphism is associated with lower sP-selectin levels. Lower levels of sP-selectin were not accounted for by this polymorphism in blacks, in whom the C allele was very rare.

Keywords

Ethnicity - polymorphism - sP-selectin - inflammation - cardiovascular disease
 

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