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Synfacts 2008(8): 0794-0794  
DOI: 10.1055/s-2008-1078535
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of (-)-Tetrodotoxin

Contributor(s): Philip Kocienski, Zofia Komsta
K.-i. Sato*, S. Akai, H. Shoji, N. Sugita, S. Yoshida, Y. Nagai, K. Suzuki, Y. Nakamura, Y. Kajihara, M. Funabashi, J. Yoshimura
Kanagawa University, Yokohama, Chiba University and Iwaki Meisei University, Japan
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Publication History

Publication Date:
23 July 2008 (online)

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Significance

(-)-Tetrodotoxin is a neurotoxin most probably produced by bacteria living in aquatic animals, like puffer fish or frogs. It selectively binds to pores of the fast voltage-gated sodium channels in nerve cell membranes.