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Synfacts 2008(8): 0893-0893  
DOI: 10.1055/s-2008-1077929
Polymer-Supported Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

A³-Coupling Reaction Catalyzed by a Supported Gold(III) Catalyst

Contributor(s): Yasuhiro Uozumi, Yutaka Matsuura
X. Zhang, A. Corma*
Universidad Politécnica de Valencia, Spain
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Publication History

Publication Date:
23 July 2008 (online)

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Significance

Three-component coupling of various aldehydes 1, amines 2, and alkynes 3 (A³ coupling) took place in the presence of supported gold catalyst (Au/CeO2 or Au/ZrO2; aldehyde: amine:alkyne = 1:1.2:1.3) to give the corresponding propargyl amines 4 in up to 99% yield (28 examples). The authors also tested gold catalysts of different support media. Au/CeO2 and Au/ZrO2 were superior to various supported catalysts, for example, Au/SiO2, Au/C, Au/TiO2, Au/Fe2O3.