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Synfacts 2008(8): 0781-0781  
DOI: 10.1055/s-2008-1077898
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of Fluostatin C

Contributor(s): Philip Kocienski, Indu Dager
M. Yu, S. J. Danishefsky*
Columbia University and Sloan-Kettering Institute for Cancer Research, New York, USA
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Publication History

Publication Date:
23 July 2008 (online)

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Significance

Fluostatin C, isolated from the fermentation broth of Streptomyces strain Acta 1383, exhibits antibiotic and antitumor activities. Achievement of a highly regioselective Diels-Alder reaction between the vinyldiene A and dienophile quinoneketal B was a critical step in the synthesis depicted here.