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Planta Med 1980; 40(12): 356-360
DOI: 10.1055/s-2008-1074985
Research Articles

© Georg Thieme Verlag Stuttgart · New York

Actions Neuromusculaire et Cardiaque d'un Extrait Alcaloïdique de Strychnos icaja

Muscle Relaxant and Cardiac Effects of an Alkaloidal Extract from Strychnos icajaK. Kambu1 , S. Kaba2 , E. Cambier3 , K. Nzuzi2 , L. Angenot4
  • 1Laboratoire de Pharmacognosie, Faculté de Pharmacie (UNAZA), Kinshasa XI, Zaïre
  • 2Laboratoire de Pharmacologie, Faculté de Pharmacie (UNAZA), Kinshasa XI, Zaïre
  • 3Laboratoire de Physiologie, Faculté de Médecine (UNAZA), Kinshasa XI, Zaïre
  • 4Laboratoire de Pharmacognosie, Faculté de Médecine, Université de Liège, Belgique
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Publication History

Publication Date:
29 April 2008 (online)

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Abstract

Strychnos icaja Baill is a well-known tetanizing poison, containing strychnine and 12-hydroxy-derivative amongst many other tertiary alkaloids. We have studied quaternary alkaloids of S. icaja root barks, which exhibit a prononced muscle-relaxant effect and a high cardiotoxicity. Our experiments prove that the pharmacological action of S. icaja aqueous extract is different from that of S. nux-v-mica extract. Therefore none african Strychnos species shows an exclusively strychnine-like effect in all its extracts.

Key Word Index

Strychnos icaja - Loganiaceae - Quaternary Alkaloids - Muscle-relaxant Effect - Cardiotoxicity.

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