Cranial MRI in PKU: Evaluation of a Critical Threshold for Blood Phenylalanine

K. Ullrich; J. Weglage; G. Schuierer; B. Fünders; M. Pietsch; H. G. Koch; H. Hahn-Ullrich

doi:10.1055/s-2008-1073039

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Neuropediatrics 1994; 25(5): 278-279
DOI: 10.1055/s-2008-1073039

Letter to the editor

Cranial MRI in PKU: Evaluation of a Critical Threshold for Blood Phenylalanine

K. Ullrich¹ , J. Weglage¹ , G. Schuierer² , B. Fünders¹ , M. Pietsch¹ , H. G. Koch¹ , H. Hahn-Ullrich¹

¹Department of Pediatrics, University of Münster, Germany
²Department of Radiology, University of Münster, Germany

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Publication History

Publication Date:
19 March 2008 (online)

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Abstract

A group of 15 adolescent patients with PKU and good life time blood phenylalanine control was tested for white matter abnormalities on MRI. Five of the patients presented mild to moderate abnormalities in association with blood phenylalanine levels above 5.0 mg/dl. Patients with and without MRI changes could statistically not be discriminated by blood phenylalanine concentrations at the time of investigation as well as by phenylalanine levels of different time periods prior to MRI examination.

Key words

Phenylketonuria - Magnetic Resonance Imaging - MRI

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