Hypometabolism and Dipole Localization in Hemimegalencephaly: A Case Report

Y. Ohta; M. Hiraiwa; K. Murayama; M. Nonaka-Mishima; Y. Kaneko; M. Yumoto; H. Yotsumoto; M. Iio

doi:10.1055/s-2008-1073031

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Neuropediatrics 1994; 25(5): 255-258
DOI: 10.1055/s-2008-1073031

Short communication

Hypometabolism and Dipole Localization in Hemimegalencephaly: A Case Report

Y. Ohta² , M. Hiraiwa² , K. Murayama³ , M. Nonaka-Mishima^1,2 , Y. Kaneko⁴ , M. Yumoto⁵ , H. Yotsumoto⁵ , M. Iio⁶

¹Department of Pediatrics, Teikyo University School of Medicine, Japan
²Toda Municipal Health Center, Japan
³Department of Pediatrics, National Rehabilitation Center for Disabled Children, Japan
⁴Department of Neurosurgery, Tokyo University School of Medicine, Japan
⁵Department of Central Laboratory, Tokyo University Hospital, Japan
⁶Department of Radiology, Nakano National Chest Hospital, Japan

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Publication History

Publication Date:
19 March 2008 (online)

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Abstract

A case of hemimegalencephaly was studied by means of neuroimaging (CT, MRI and PET) and magnetoencephalography (MEG). Hemimegalencephaly (HM) is a neuronal migration disorder. This is the first report of evaluation of HM with the use of PET and MEG from not only the morphological but also the functional point of view. PET with 11C-glucose showed a low radioactive concentration in the affected hemisphere, which suggested a metabolic deficit. MEG proved the epileptic foci existed mainly in the affected hemisphere, especially around a heterotopia and the pachygyric cortex, which was disclosed on MRI.

Key words

Hemimegalencephaly - PET - MRI - Magnetoencephalography - Infantile spasms

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