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Synthesis 2008(19): 3061-3064  
DOI: 10.1055/s-2008-1067252
PAPER
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of a Hydroxyethylene Dipeptide Isostere, a Core Unit of the HIV Protease Inhibitors Ritonavir and Lopinavir, and Its C-5 Epimer

Gopishetti Bhaskar, Anchoori Ravi Kumar, Errabelli Ramu, Batchu Venkateswara Rao*
Organic Chemistry Division-III, Indian Institute of Chemical Technology, Hyderabad 500007, India
Fax: +91(40)27193003; e-Mail: venky@iict.res.in;
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Publication History

Received 14 May 2008
Publication Date:
04 September 2008 (online)

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Abstract

A short synthesis of a hydroxyethylene dipeptide iso­stere, a core unit of the HIV protease inhibitors ritonavir and lopinavir, and its C-5 epimer is described.

Key words

HIV-AIDS - peptidomimetic aspartyl protease inhibitors - regioselective epoxide opening

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