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Synthesis 2008(13): 2141-2147  
DOI: 10.1055/s-2008-1067125
PAPER
© Georg Thieme Verlag Stuttgart · New York

A Concise Synthesis of Mono- and Polysubstituted and Diversely N-Function­alized Isoindolinones and Isoquinolones

Magali Loriona,b, Axel Couture*a,b, Eric Deniaua,b, Pierre Grandclaudona,b
a LCOP, Université des Sciences et Technologies de Lille 1, Bâtiment C3(2), 59655 Villeneuve d’Ascq, France
Fax: +33(3)20336309; e-Mail: axel.couture@univ-lille1.fr;
b CNRS, UMR 8009 ‘Chimie Organique et Macromoléculaire’, 59655 Villeneuve d’Ascq, France
Further Information

Publication History

Received 4 April 2008
Publication Date:
11 June 2008 (online)

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Abstract

A variety of differently substituted and diversely N-(sulfanyl)hydroxyalkyl functionalized isoindolinones and isoquinol­ones have been obtained by anionic cyclization of cyclic bromobenzyl or bromophenethylcarbamates and thiocarbamates.

Key words

lactams - carbanions - ring closure - ring opening - bicyclic compounds

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