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Synfacts 2008(4): 0331-0331
DOI: 10.1055/s-2008-1042889
DOI: 10.1055/s-2008-1042889
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York
Synthesis of (±)-Clusianone
J. Qi, J. A. Porco, Jr.*
Boston University, USA
Further Information
Publication History
Publication Date:
19 March 2008 (online)
Significance
Clusianone is isolated from the floral resin of the Clusia species. It has promising biological activity and the interesting bicyclo[3.3.0] core has made clusianone a popular target. This synthesis utilizes an alkylative dearomatization strategy to construct the bicyclic core.