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Synfacts 2008(4): 0402-0402  
DOI: 10.1055/s-2008-1042867
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York

Nickel(II)-Catalyzed Enantioselective 1,3-Dipolar Cycloadditions

Contributor(s): Hisashi Yamamoto, Marina Naodovic
J.-W. Shi, M.-X. Zhao, Z.-Y. Lei, M. Shi*
East China University of Science and Technology, Shanghai and Shanghai Institute of Organic Chemistry, P. R. of China
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Publication History

Publication Date:
19 March 2008 (online)

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Significance

Although there are several protocols developed for asymmetric 1,3-dipolar cyclo­addition reactions, this is one of the first examples of a Ni-catalyzed variant. Using low catalyst loadings under mild conditions, the products are obtained in good to excellent yields and high enantioselecti­vities. The chiral ligand used is easily prepared from commercially available precursors.