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Fortschr Neurol Psychiatr 2008; 76: S8-S15
DOI: 10.1055/s-2008-1038140
Originalarbeit
© Georg Thieme Verlag Stuttgart · New York

Funktionelle Bildgebung von Emotionen und emotionalen Dysfunktionen bei schizophrenen Patienten

Functional Imaging of Emotions and Emotional Dysfunctions in Schizophrenia PatientsF.  Schneider1 , M.  Reske1, 2 , V.  Backes1 , U.  Habel1
  • 1Klinik für Psychiatrie und Psychotherapie, Universitätsklinikum Aachen, RWTH Aachen University
  • 2Laboratory of Biological Dynamics and Theoretical Medicine, Department of Psychiatry, University of California, San Diego
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Publication History

Publication Date:
07 May 2008 (online)

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Zusammenfassung

Emotionen rücken, wenngleich schon in früher psychiatrischer Fachliteratur thematisiert, erst jetzt wieder zunehmend in den Fokus neuropsychiatrischer Forschung. Dies ist einerseits auf die herausragende Bedeutung für die Symptomatologie psychiatrischer Erkrankungen, andererseits aber auch auf die technische Weiterentwicklung im Bereich der funktionellen Bildgebung zurückzuführen. Diese erst ermöglicht die notwendigen komplexen Untersuchungsparadigmen. Insbesondere schizophrene Patienten zeigen in verschiedenen Studien zu emotionalen Prozessen Defizite, z. B. bei Paradigmen der Stimmungsinduktion oder der Emotionsdiskrimination. Diskutiert wird insbesondere, inwiefern emotionale Dysfunktionen über verschiedene Phasen der Erkrankung, möglicherweise bereits im Prodromalstadium, nachweisbar sind. Hierfür ist es hilfreich, auch jugendliche Patienten mit ersten psychosenahen Symptomen zu untersuchen. Für die Zukunft wird es von besonderer Bedeutung sein, den Einfluss von Emotionen auf kognitive Funktionen bei Gesunden und bei psychiatrischen Patienten zu untersuchen und differenzielle Unterschiede zu charakterisieren.

Abstract

Emotions have been discussed in earliest psychiatric literature as core characteristics of psychiatric patients. More recently emotions got back into the focus of modern neuropsychiatric imaging research. This is due to the outstanding importance of emotions for psychiatric symptomatology and also to recent technical developments in neuroimaging, which lay the ground for more complex paradigms. Especially schizophrenic patients show deficits in emotional functioning, such as in mood induction or emotion discrimination. It is subject to discussion how stable these dysfunctions are over the course of schizophrenia, e. g. in prodromal stage. Therefore research also deals with juvenile patients with schizophrenia-like symptoms. In the future it will be essential to characterize the effect of emotions on cognitive functions in healthy subjects and psychiatric patients.

Schlüsselwörter

Emotionen - Schizophrenie - Bildgebung

Key words

emotions - schizophrenia - imaging

Literatur

  • 1 Bleuler E. Dementia praecox oder Die Gruppe der Schizophrenien. Handbuch der Psychiatrie. Aschaffenburg: Deuticke 1911
    Google Scholar
  • 2 Kraepelin E. Dementia praecox. Übersetzung von Barclay RM. Edinburgh: Livingstone 1919
    Google Scholar
  • 3 Kohler C G, Bilker W, Hagendoorn M, Gur R E, Gur R C. Emotion recognition deficit in schizophrenia: association with symptomatology and cognition.  Biol Psychiatry. 2000;  48 127-136
    Google Scholar
  • 4 Schneider F, Gur R C, Gur R E, Shtasel D L. Emotional processing in schizophrenia: neurobehavioral probes in relation to psychopathology.  Schizophr Res. 1995;  17 67-75
    Google Scholar
  • 5 Kee K S, Horan W P, Mintz J, Green M F. Do the siblings of schizophrenia patients demonstrate affect perception deficits?.  Schizophr Res. 2004;  67 87-94
    Google Scholar
  • 6 Addington J, Addington D. Visual attention and symptoms in schizophrenia: a 1-year follow-up.  Schizophr Res. 1998;  34 95-99
    Google Scholar
  • 7 Wölwer W, Streit M, Polzer U, Gaebel W. Facial affect recognition in the course of schizophrenia.  Eur Arch Psychiatry Clin Neurosci. 1996;  246 165-170
    Google Scholar
  • 8 Hooker C, Park S. Emotion processing and its relationship to social functioning in schizophrenia patients.  Psychiatry Res. 2002;  112 41-50
    Google Scholar
  • 9 Kee K S, Green M F, Mintz J, Brekke J S. Is emotion processing a predictor of functional outcome in schizophrenia?.  Schizophr Bull. 2003;  29 487-497
    Google Scholar
  • 10 Mandal M K, Jain A, Haque-Nizamie S, Weiss U, Schneider F. Generality and specificity of emotion-recognition deficit in schizophrenic patients with positive and negative symptoms.  Psychiatry Res. 1999;  87 39-46
    Google Scholar
  • 11 Davis P J, Gibson M G. Recognition of posed and genuine facial expressions of emotion in paranoid and nonparanoid schizophrenia.  J Abnorm Psychol. 2000;  109 445-450
    Google Scholar
  • 12 Cardno A G, Holmans P A, Harvey I, Williams M B, Owen M J, McGuffin P. Factor-derived subsyndromes of schizophrenia and familial morbid risks.  Schizophr Res. 1997;  23 231-238
    Google Scholar
  • 13 Os J van, Marcelis M, Sham P, Jones P, Gilvarry K, Murray R. Psychopathological syndromes and familial morbid risk of psychosis.  Br J Psychiatry. 1997;  170 241-246
    Google Scholar
  • 14 Schneider F, Grodd W, Weiss U, Klose U, Mayer K R, Nägele T, Gur R. Functional MRT reveals left amygdala activation during emotion.  Psychiatry Res. 1997;  76 75-82
    Google Scholar
  • 15 Habel U, Klein M, Shah N J, Toni I, Zilles K, Falkai P, Schneider F. Genetic load on amygdala hypofunction during sadness in non-affected brothers of schizophrenia patients.  Am J Psychiat. 2004;  161 1806-1813
    Google Scholar
  • 16 Schneider F, Weiss U, Kessler C, Salloum J, Posse S, Grodd W, Müller-Gärtner H-W. Differential amygdala activation in schizophrenia during sadness.  Schizophr Res. 1998;  34 133-142
    Google Scholar
  • 17 Schneider F, Habel U, Reske M, Toni I, Zilles K, Falkai P, Shah N J. Neural substrates of olfactory processing in schizophrenia patients and their healthy relatives.  Psychiatry Res. 2007;  155 103-112
    Google Scholar
  • 18 Gur R E, McGrath C, Chan R M, Schroeder L, Turner T, Turetsky B I, Kohler C, Alsop D, Maldjian J, Ragland J D, Gur R C. An fMRT study of facial emotion processing in patients with schizophrenia.  Am J Psychiatry. 2002;  159 1992-1999
    Google Scholar
  • 19 Schneider F, Gur R C, Koch K, Backes V, Amunts K, Shah N J, Bilker W, Gur R E, Habel U. Impairment in the specificity of emotion processing in schizophrenia.  Am J Psychiat. 2006;  163 442-447
    Google Scholar
  • 20 Frommann N, Streit M, Wolwer W. Remediation of facial affect recognition impairments in patients with schizophrenia: a new training program.  Psychiatry Res. 2003;  117 281-284
    Google Scholar
  • 21 Gray J R. Emotional modulation of cognitive control: approach-withdrawal states double-dissociate spatial from verbal two-back task performance.  J Exp Psychol Gen. 2001;  130 436-452
    Google Scholar
  • 22 Drevets W C, Raichle M E. Reciprocal Suppression of Regional Cerebral Blood Flow during Emotional versus Higher Cognitive Processes: Implications for Interactions between Emotion and Cognition.  Cognition Emotion. 1998;  12 353-385
    Google Scholar
  • 23 Bartolic E I, Basso M R, Schefft B K, Glauser T, Titanic-Schefft M. Effects of experimentally-induced emotional states on frontal lobe cognitive task performance.  Neuropsychologia. 1999;  37 677-683
    Google Scholar
  • 24 Perlstein W M, Elbert T, Stenger V A. Dissociation in human prefrontal cortex of affective influences on working memory-related activity.  Proc Natl Acad Sci U S A. 2002;  99 1736-1741. Epub 2002 [Erratum: 2002; 99: 4753]
    Google Scholar
  • 25 Cameron A M, Oram J, Geffen G M, Kavanagh D J, McGrath J J, Geffen L B. Working memory correlates of three symptom clusters in schizophrenia.  Psychiatry Res. 2002;  110 49-61
    Google Scholar
  • 26 Sanfilipo M, Lafargue T, Rusinek H, Arena L, Loneragan C, Lautin A, Rotrosen J, Wolkin A. Cognitive performance in schizophrenia: relationship to regional brain volumes and psychiatric symptoms.  Psychiatry Res. 2002;  116 1-23
    Google Scholar
  • 27 Schneider F, Habel U, Kessler C, Salloum J B, Posse S. Gender differences in regional cerebral activity during sadness.  Hum Brain Mapp. 2000;  9 226-238. [Erratum: 2001; 13: 124]
    Google Scholar
  • 28 Zucco G, Caldironi P, Schoch V. Preferenze olfattive e comunicazione olfattiva in soggetti ciechi pluri-handicappati: una ricerca qualitativa.  Contributi Psicologia. 1989;  2 131-144
    Google Scholar
  • 29 Sobel N, Prabhakaran V, Desmond J E, Glover G H, Goode R L, Sullivan E V, Gabrieli J D. Sniffing and smelling: separate subsystems in the human olfactory cortex.  Nature. 1998;  392 282-286
    Google Scholar
  • 30 Schneider F, Koch K, Reske M, Kellermann T, Seiferth N, Stöcker T, Amunts K, Shah N J, Habel U. Interaction of negative olfactory stimulation and working memory in schizophrenia patients: development and evaluation of a behavioral neuroimaging task.  Psychiatry Res. 2006;  144 123-130
    Google Scholar
  • 31 Levesque J, Eugene F, Joanette Y, Paquette V, Mensour B, Beaudoin G, Leroux J M, Bourgouin P, Beauregard M. Neural circuitry underlying voluntary suppression of sadness.  Biol Psychiatry. 2003;  53 502-510
    Google Scholar
  • 32 Posse S, Fitzgerald D, Gao K, Habel U, Rosenberg D, Moore G J, Schneider F. Real-time fMRI of temporolimbic regions detects amygdala activation during single-trial self-induced sadness.  Neuroimage. 2003;  18 760-768
    Google Scholar
  • 33 Seiferth N Y, Pauly K, Habel U, Kellermann T, Jon Shah N, Ruhrmann S, Klosterkötter J, Schneider F, Kircher T. Increased neutral response related to neutral faces in individuals at risk for psychosis.  Neuroimage. 2008;  40 289-297
    Google Scholar

Prof. Dr. Dr. Frank Schneider

Klinik für Psychiatrie und Psychotherapie, Universitätsklinikum

Pauwelsstr. 30

52074 Aachen

Email: fschneider@ukaachen.de

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