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Am J Perinatol 1998; 15(9): 533-534
DOI: 10.1055/s-2007-994055
ORIGINAL ARTICLE

© 1998 by Thieme Medical Publishers, Inc.

Rapid Marked Response of Severe Hyperemesis Gravidarum to Oral Erythromycin

Cherif M. El Younis1 , Ovadia Abulafia2 , David M. Sherer1 , 2 , 3
  • 1Division of Gastroenterology, The Department of Internal Medicine, State University of New York, Health and Science Center, Brooklyn, New York
  • 2The Department of Obstetrics and Gynecology, State University of New York, Health and Science Center, Brooklyn, New York
  • 3The Division of Maternal-Fetal Medicine, The Department of Obstetrics & Gynecology and Women's Health, Montefiore Medical Center, The Albert Einstein College of Medicine, Bronx, New York
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Publication History

Publication Date:
04 March 2008 (online)

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ABSTRACT

A recent report has noted an association between Helicobacter pylori and hyper-emesis gravidarum. We present two cases in which first-trimester patients with severe hyperemesis gravidarum requiring intravenous fluid replacement were placed on oral erythromycin therapy for other nonrelated conditions. Surprisingly, marked rapid improvement of the hyperemesis gravidarum was observed with complete resolution of all symptomatology. Both these patients tested seropositive for Helicobacter pylori. These unexpected, marked therapeutic responses are consistent with the recently reported association between hyperemesis gravidarum and Helicobacter pylori and possibly suggest a new therapeutic modality for similar patients.

Keywords

Hyperemesis gravidarum - helicobacter pylori - oral erythromycin

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