Hydrogen-Bond-Promoted C-C Bond-Forming Reaction: Catalyst-Free Michael Addition Reactions in Ethanol

Abstract

A practical protocol for catalyst-free Michael addition reactions in ethanol was developed. The reaction was promoted efficiently in alcohol without any additives, and the importance of hydrogen-bonding activation was suggested.

Key words

alcohols - green chemistry - Michael additions - solvent effects - enols

References and Notes

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14

Amount of EtOH could be reduced to 0.10 mL without loss of reactivity.