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Synfacts 2007(12): 1233-1233
DOI: 10.1055/s-2007-991314
DOI: 10.1055/s-2007-991314
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York
Synthesis of (-)-d-erythro-Sphingosine
H. Yang, L. S. Liebeskind*
Emory University, Atlanta, USA
Further Information
Publication History
Publication Date:
22 November 2007 (online)
Significance
Sphingosine is the core component of the sphingolipids, which have various appendages on the terminal hydroxy group. Sphingolipids show promising activity against cancer as they control various factors of cell growth. This synthesis excels over previous syntheses due to its brevity and the retention of high enantiopurity throughout the synthesis.