Enantioselective Total Synthesis of the Antifungal Agent (6S)-5,6-Dihydro-6-[(2R)-2-hydroxy-6-phenylhexyl]-2H-pyran-2-one [1]

Abstract

An enantioselective route for the synthesis of (6S)-5,6-dihydro-6-[(2R)-2-hydroxy-6-phenylhexyl]-2H-pyran-2-one is reported. The synthesis is based on epoxide ring opening with a Grignard reagent and stereoselective reduction employing catecholborane as key reactions.

Key words

6-substituted 5,6-dihydro-2H-pyran-2-ones - catecholborane - antifungal activity

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IICT Communication No. 061205

References

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IICT Communication No. 061205