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Skull Base 2007; 17(6): 405-407
DOI: 10.1055/s-2007-986459
CASE REPORT

© Thieme Medical Publishers

Noncontiguous Bilateral Esthesioneuroblastoma: A Case Report

Annesse Lee1 , David P. Goldstein2 , Jonathan Irish3 , Fred Gentili4 , Bayardo Perez-Ordonez5
  • 1Division of Otolaryngology-Head and Neck Surgery, McMaster University, Hamilton, Ontario, Canada
  • 2Department of Otolaryngology-Head and Neck Surgery, University Health Network, University of Toronto, Toronto, Ontario, Canada
  • 3Department of Surgical Oncology, Princess Margaret Hospital, University of Toronto, Toronto, Ontario, Canada
  • 4Division of Neurosurgery, University Health Network, University of Toronto, Toronto, Ontario, Canada
  • 5Department of Pathology, University Health Network, University of Toronto, Toronto, Ontario, Canada
Further Information

Publication History

Publication Date:
04 September 2007 (online)

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ABSTRACT

Esthesioneuroblastoma is a rare malignant neoplasm arising from the olfactory epithelium. This tumor has a tendency to originate from one side of the nasal cavity or paranasal sinuses with frequent extension into the contralateral nasal cavity through direct invasion. A review of the literature reveals numerous case reports describing esthesioneuroblastoma with unilateral or bilateral involvement; however, there have been no known reports of bilateral noncontiguous (multifocal) esthesioneuroblastoma. We present a unique case of a patient diagnosed with two separate primary esthesioneuroblastomas who was managed with preoperative radiation followed by surgical resection of the tumor. This case illustrates that esthesioneuroblastoma must remain as part of the differential diagnosis for a multifocal, noncontiguous intranasal and paranasal sinus mass.

KEYWORDS

Esthesioneuroblastoma - noncontiguous sinus mass - olfactory neuroblastoma

REFERENCES

  • 1 Cummings C W. Cummings Otolaryngology: Head and Neck Surgery. 4th ed. St. Louis; Mosby Inc 2005: 3915
    Google Scholar
  • 2 Berger L, Luc H, Richard R. L'esthesioneuro epitheliome olfactif.  Bull Assoc Fr Etud Cancer. 1924;  13 410-420
    PubMedGoogle Scholar
  • 3 Morita A, Ebersold M J, Olsen K D et al.. Esthesioneuroblastoma: prognosis and management.  Neurosurgery. 1993;  32 706-715
    CrossrefPubMedGoogle Scholar
  • 4 Simon J H, Zehn W, McCulloch T M et al.. Esthesioneuroblastoma: the University of Iowa experience 1978-1998.  Laryngoscope. 2001;  111 488-493
    CrossrefPubMedGoogle Scholar
  • 5 Bradley P J, Jones N S, Robertson I. Diagnosis and management of esthesioneuroblastoma.  Curr Opin Otolaryngol Head Neck Surg. 2003;  11 112-118
    CrossrefPubMedGoogle Scholar
  • 6 Ogura J H, Schenek N L. Unusual nasal tumors: problems in diagnosis and treatment.  Otolaryngol Clin North Am. 1973;  6 813-837
    PubMedGoogle Scholar
  • 7 Townsend C. Sabiston Textbook of Surgery. 17th ed. St. Louis; Saunders 2004: 847
    Google Scholar
  • 8 Tsue T T, Bailet J W, Barlow D W, Makielski K H. Bilateral sinonasal papillomas in aplastic maxillary sinuses.  Am J Otolaryngol. 1997;  18 263-268
    PubMedGoogle Scholar
  • 9 Ejaz A, Wenig B. Sinonasal undifferentiated carcinoma: clinical and pathologic features and a discussion on classification, cellular differentiation, and differential diagnosis.  Adv Anat Pathol. 2005;  12 134-143
    CrossrefPubMedGoogle Scholar
  • 10 Dulguerov P, Calcaterra T. Esthesioneuroblastoma. Emedicine [serial online] 2002
    Google Scholar

Annesse LeeM.D. 

Division of Otolaryngology-Head and Neck Surgery, McMaster University

3V1-1200 Main Street West, Hamilton, Ontario, Canada L8N 3Z5

Email: Annesse.Lee@learnlink.mcmaster.ca

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