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Synfacts 2007(10): 1107-1107
DOI: 10.1055/s-2007-968959
DOI: 10.1055/s-2007-968959
Polymer-Supported Synthesis
© Georg Thieme Verlag Stuttgart · New York
Hydrosilylation Catalyzed by the [Silica]-SMAP-Rh System
G. Hamasaka, A. Ochida, K. Hara, M. Sawamura*
Hokkaido University, Sapporo, Japan
Further Information
Publication History
Publication Date:
07 November 2007 (online)
Significance
The compact phosphine 3 was immobilized on silica gel, which was found to be a highly effective ligand for the Rh-catalyzed hydrosilylation of various ketones. TfO-SMAP 2 was prepared via the protodesilylation of 1, and was covalently anchored onto HCl-activated silica gel to give [silica]-SMAP 3. The immobilized phosphine 3 was used as a ligand in the Rh-catalyzed hydrosilylation of ketones 4 where the corresponding silyl ethers 5 were obtained with excellent yields. The Rh-3 catalyst could be recoverd by simple filtration and be reused without loss of catalytic activity.