Subscribe to RSS
Please copy the URL and add it into your RSS Feed Reader.
https://www.thieme-connect.de/rss/thieme/en/10.1055-s-00000131.xml
Synfacts 2007(10): 1092-1092
DOI: 10.1055/s-2007-968937
DOI: 10.1055/s-2007-968937
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart · New York
Nickel-Catalyzed Intermolecular Reductive Coupling of Enones and Alkynes
A. Herath, B. B. Thompson, J. Montgomery*
University of Michigan, Ann Arbor, USA
Further Information
Publication History
Publication Date:
07 November 2007 (online)
Significance
A Ni-catalyzed intermolecular coupling of enones with alkynes is reported. In contrast to their aldehyde counterparts no ring closure is observed. Couplings with aromatic alkynes or ynoates proceed with high regioselectivities, whereas nonaromatic internal alkynes deliver product mixtures.