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Synfacts 2007(6): 0571-0571  
DOI: 10.1055/s-2007-968515
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Synthesis of Paliurine F

Contributor(s): Philip Kocienski, Stewart Eccles
M. Toumi, F. Couty, G. Evano*
Université de Versailles Saint Quentin en Yvelines, France
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Publication History

Publication Date:
22 May 2007 (online)

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Significance

Paliurine F is one of over 200 macrocyclic enamide-containing cyclopeptide alkaloids. This synthesis uses a copper-catalyzed amidation to install both the macrocyclic and enamide functionalities.