Ir-Catalyzed Borylation and Sequential Functionalization of Arenes

Significance

The Ir-catalyzed borylation of aromatic compounds represents a new useful method for the preparation of polyfunctionalized arylboronates, which have become extremely important intermediates in modern organic synthesis. This reaction is complementary to the usual preparation of arylboronic acids. It requires only a quite low amount of the Ir catalyst and usually offers excellent yields of products. If the resulting arylboron compounds are transformed into anilines and aryl ethers, this method presents a simple functionalization of an arene C-H bond.