Palladium-Catalyzed Arylation of Imines

Significance

The transition-metal-catalyzed addition of carbon nucleophiles onto carbon-hetero­atom double bonds has attracted considerable attention recently due to the possibility to generate chiral amines. The authors use a cationic achiral palladium complex to add arylboronic acids to activated S-chiral imines and can isolate arylglycine derivatives in moderate to high yields and high dia­stereomeric excesses. The cleavage of the directing group yields aryl-substituted non-natural amino acids.