Download PDF
Horm Metab Res 1981; 13(9): 486-491
DOI: 10.1055/s-2007-1019313
© Georg Thieme Verlag, Stuttgart · New York

Abnormal Insulin Secretion in Adult Canines

H. P. Chin, C. E. Atkins, R. Barndt
  • University of Southern California, Department of Medicine, School of Medicine, Los Angeles, California, and Oklahoma State University, Department of Medicine and Surgery, College of Veterinary Medicine, Stillwater, Oklahoma, U.S.A.
Further Information

Publication History

1980

1980

Publication Date:
14 March 2008 (online)

Also available at
  PDF Download  Permissions and Reprints

Summary

Insulin secretion after intravenous administration of glucose was studied in fourteen dogs, twelve of which were four years of age or older. Based on several characteristics of insulin secretion kinetics, normal and impaired insulin responses were defined in the experimental subjects. Among those, five exhibited a marked depression of the initial stage of insulin release which was followed by a stage of relative hyperinsulinemia. Similarities between canine and human insulin secretion patterns were noted, and the potential usefulness of the procedure for the early detection of canine diabetes mellitus discussed.

Key-Words:

Glucose Tolerance - Intravenous - Diabetes Mellitus - Secondary Hyperinsulinemia - Impaired Insulin Response

      >