Download PDF
Horm Metab Res 1981; 13(2): 107-109
DOI: 10.1055/s-2007-1019186
© Georg Thieme Verlag, Stuttgart · New York

Thyrotrophin and Prolactin Response to β-(Pyrazolyl-1)-Alanine-2-TRH in Normal Males

J. A. Garcia-Centenera, J. M. Vilchez-Lafuente, F. Hervas, J. P. Alba, V. Pozuelo, D. H. Coy, A. V. Schally1
  • Escuela Iberoamericana de Endocrinologia, Facultad de Medicina, Madrid, Spain
  • 1Veterans Administration Medical Center and Tulane University School of Medicine, New Orleans, Louisiana, USA
Further Information

Publication History

1980

1980

Publication Date:
14 March 2008 (online)

Also available at
  PDF Download  Permissions and Reprints

Summary

Synthetic β-(pyrazolyl-1)-alanine-2-TRH, an analog of thyrotropin releasing hormone (TRH) was administered intravenously in doses of 50, 100 and 200 μg to four normal men in order to establish the range of responses of TSH and prolactin. Every subject showed a clear elevation in TSH and prolactin levels with all three doses. These results were compared with the increments in TSH and prolactin after the administration of the same doses of synthetic TRH. The computations of potency for absolute levels and/or increments in TSH and prolactin at 20 and 40 min showed that the analog was at least twice as active as TRH in releasing TSH and prolactin.

Key-Words:

Analog or TRH - TSH Increments - Prolactin Release

      >