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Planta Med 1992; 58(6): 535-539
DOI: 10.1055/s-2006-961544
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© Georg Thieme Verlag Stuttgart · New York

Inhibitory Effect of Tannic Acid Sulfate and Related Sulfates on Infectivity, Cytopathic Effect, and Giant Cell Formation of Human Immunodeficiency Virus

Takashi Mizuno1 , Keijiro Uchino1 , Toshikatsu Toukairin1 , Akiko Tanabe2 , Hideki Nakashima2 , Naoki Yamamoto2 , Hiroshi Ogawara3
  • 1Central Laboratory, Nippon Flour Mills Co., Ltd., 2114-2, Nurumizu, Atsugi, Kanagawa 243, Japan
  • 2Department of Virology and Parasitology, Yamaguchi University, School of Medicine, 1114, Kogushi, Ube, Yamaguchi 755, Japan
  • 3Department of Biochemistry, Meiji College of Pharmacy, Nozawa-1, Setagaya-ku, Tokyo 154, Japan
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Publication History

1991

Publication Date:
05 January 2007 (online)

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Abstract

The acquired immune deficiency syndrome (AIDS) is thought to result from infection of T cells by a pathogenic human retrovirus, human immunodeficiency virus [HIV (HTLV-III/LAV)]. In this report, we synthesized sulfated plant polyphenols such as tannic acid sulfate, rutin sulfate, ellagic acid sulfate, (-)-epicatechin sulfate, and (-)-epigallocatechin 3-gallate sulfate, and examined the in vitro inhibitory effect on HIV infection using human T-cell lymphotropic virus type-I-carrying MT-4 cells, which are extremely susceptible to HIV infection. Of the compounds tested, tannic acid sulfate was the most effective and had low cytotoxicity. Tannic acid sulfate completely inhibited the cytopathic effect of HIV and the HIV-specific antigen expression in MT-4 cells at the concentration of 6 μg/ml. In addition, this sulfate inhibited giant cell formation in coculture at the concentration of 5 μg/ml.

Key words

Tannic acid sulfate - sulfated polyphenol - AIDS - human immunodeficiency virus - cytopathic effect - giant cell formation.

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