Cytotoxic and Antiparasitic Activity from Annona senegalensis Seeds*

Sevser Sahpaz; Ch. Bories; P. M. Loiseau; D. Cortès; R. Hocquemiller; A. Laurens; A. Cavé

doi:10.1055/s-2006-959566

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Planta Med 1994; 60(6): 538-540
DOI: 10.1055/s-2006-959566

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Cytotoxic and Antiparasitic Activity from Annona senegalensis Seeds*

Sevser Sahpaz¹ , Ch. Bories² , P. M. Loiseau² , D. Cortès¹ , R. Hocquemiller¹ , A. Laurens¹ , A. Cavé¹

¹Laboratoire de Pharmacognosie, URA CNRS 496, Faculté de Pharmacie, Université Paris-Sud, F-92290 Châtenay-Malabry, France
²Laboratoire de Parasitologie, Faculté de Pharmacie, Université Paris-Sud, F-92290 Châtenay-Malabry, France

* Part 32 in the series “Acetogenins from Annonaceae”; for part 31, see: Ph. Duret, D. Gromek, R. Hocquemiller, D. Cortès and A. Cavé (1994); J. Nat. Prod., in press.

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Publication History

1993

1994

Publication Date:
05 January 2007 (online)

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Abstract

Several extracts of Annona senegalensis (Annonaceae) seeds were tested for antiparasitic activity against Leishmania major, Leishmania donovani, Trypanosoma brucei brucei, and for cytotoxic activity against KB and VERO cell lines. Fractionation of seeds extracts was mainly guided by means of a biocidal assay against Artemia salina nauplii. The biological activities resulted from extract-isolated acetogenins.

Key words

Annona senegalensis - Annonaceae - acetogenins - cytotoxicity - Trypanosoma - Leishmania

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