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Synthesis 2007(2): 259-262  
DOI: 10.1055/s-2006-958946
PAPER
© Georg Thieme Verlag Stuttgart · New York

Nucleophilic Substitution of Halogens with Amines in 2- and 4-Nitrophenols

Zbigniew Wróbel*, Andrzej Kwast
Institute of Organic Chemistry, Polish Academy of Sciences, ul. Kasprzaka 44/52, 01-224 Warsaw, Poland
Fax: +48(22)6318788.; e-Mail: wrobel@icho.edu.pl;
Further Information

Publication History

Received 11 October 2006
Publication Date:
14 December 2006 (online)

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Abstract

Fluorine and chlorine in halonitrophenols are efficiently replaced with alkylamines in acetonitrile or in an excess of the amine at elevated temperature.

Key words

amines - nucleophilic aromatic substitutions - phenols - arenes

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