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Planta Med 1996; 62(4): 381-382
DOI: 10.1055/s-2006-957916
DOI: 10.1055/s-2006-957916
Letters
© Georg Thieme Verlag Stuttgart · New York
Active Constituents Against HIV-1 Protease from Garcinia mangostana
Further Information
Publication History
1995
1996
Publication Date:
04 January 2007 (online)
Abstract
The ethanol extract of Garcinia mangostana L. (Guttiferae) showed potent inhibitory activity against HIV-1 protease. The activity-guided purification of the extract resulted in the isolation of two active, known compounds. The chemical structures of the isolated compounds were established by spectroscopic analyses as mangostin (IC50 = 5.12 ± 0.41 µM) and γ-mangostin (IC50 = 4.81 ± 0.32 µM). The type of inhibition by both compounds is noncompetitive.