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Planta Med 1997; 63(2): 161-165
DOI: 10.1055/s-2006-957636
Papers
Natural Product Chemistry
© Georg Thieme Verlag Stuttgart · New York

Antineoplastic Agents II: Four Furostanol Glycosides from Rhizomes of Dioscorea collettii var. hypoglauca

Ke Hu1 , Aijun Dong2 , Xinsheng Yao1 , Hisayoshi Kobayashi3 , Shigeo Iwasaki3
  • 1Department of Phytochemistry, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, Liaoning 110015, People's Republic of China
  • 2Institute of Northeast General Pharmaceutical Factory, 37 Zhonggong Beijie, Shenyang, Liaoning 110026, People's Republic of China
  • 3Institute of Molecular and Cellular Biosciences, The University of Tokyo, Yayoi, Bunkyo-ku, Tokyo 113, Japan
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Publication History

1996

1996

Publication Date:
04 January 2007 (online)

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Abstract

During activity-guided fractionations to screen for antineoplastic agents, further studies by means of preparative HPLC led to the isolation of four known furostanol saponins: protoneodioscin, protodioscin, protoneogracillin, protogracillin, along with their corresponding artifacts: methyl protoneodioscin, methyl protodioscin, methyl protoneogracillin, and methyl protogracillin, from the rhizomes of Dioscorea collettii var. hypoglauca. Among them, protoneodioscin, protodioscin, and protoneogracillin are first reported from the title plant. The structures of the compounds were established on the basis of chemical evidence and spectral analysis (1H-NMR, 13C-IMMR, 1H-1H COSY, HMQC, HMBC, and FAB-MS). These eight compounds all caused morphological abnormality of Pyricularia oryzae mycelia. They also showed cytotoxic activities against the cancer cell line of K562 in vitro as antineoplastic agents.

key words

Dioscorea collettii var. hypoglauca - Dioscoreaceae - furostanol saponins - protodioscin - protoneodioscin - protogracillin - protoneogracillin - Pyricularia oryzae - antineoplastic agents

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